Rosie O'Donnell Targets Donald Trump in Kimmel Guest Hosting Stint

Comedian Rosie O'Donnell concluded her week as guest host of Jimmy Kimmel Live! on August 21, 2026, with a monologue featuring sharp criticisms of President Donald Trump and Secretary of Health and Human Services Robert F. Kennedy Jr. O'Donnell, who had previously moved to Ireland following the 2024 election, used the platform to address her return to the United States and her decades-long feud with the president.

During her appearances, O'Donnell referred to the president as a "hungry, hungry hypocrite" and "Orange Voldemort," while mocking Kennedy Jr. as "SpongeBob Smallpox" and questioning his medical expertise. She also referenced Project 2025 and made remarks regarding Senator Jon Ossoff and Natalie Harp.

The White House responded to the performance through spokesperson Davis Ingle. Ingle defended the administration by calling O'Donnell a "nasty woman and a total slob" and claiming her brain had been "completely destroyed by Trump Derangement Syndrome."